In patients with exudative age-related macular degeneration (AMD), greater subfoveal choroidal thickness (SFCT) at presentation correlated with need for more injections during the first year of anti-VEGF therapy, according to findings of a retrospective study conducted at the Cleveland Clinic Cole Eye Institute, Cleveland.
“We know that abnormalities in choroidal circulation are involved in AMD pathogenesis and that the choroid tends to be thinner in eyes of patients with AMD compared to age-matched healthy controls,” said Aleksandra V. Rachitskaya, MD, assistant professor of ophthalmology, Cleveland Clinic Lerner College of Medicine. “Although there is significant variation in this feature, we hypothesized that greater thickness of the subfoveal choroid in exudative AMD eyes might be a positive prognostic factor.
“Therefore, we were surprised to find that eyes with a thicker subfoveal choroid required more injections,” Dr. Rachitskaya added. “Our data suggest that imaging to determine SFCT may be helpful to retina specialists for anticipating how individuals with exudative AMD may respond to anti-VEGF injections.”
Dr. Rachitskaya said further research is needed to investigate these results in larger populations of patients of different age, race, and undergoing various treatment protocols.