With all the technological and medical advances for the treatment of diabetic eye diseases, retinal specialists still have an ongoing therapy issue because patients require continual and constant monitoring and maintenance, said Rishi P. Singh, MD.
"Unfortunately for our patients, vision gains are limited and in a minority of patients," said Dr. Singh, of the Cole Eye Institute.
Dr. Singh is this year's ASRS President's Retina Young Investigators Award recipient. Dr. Singh concentrated his lecture on the outstanding questions in diabetic eye disease researchers attempted to answer last year.
For instance, what can imaging tell clinicians about the cause of vascular diseases, in particular, diabetic retinopathy (DR)?
"Is DR truly just a retinal disease or is it a disease of the entire eye?" Dr. Singh asked. "What affect do baseline factors have on the progression of the disease and treatment outcomes? How can we best prevent complications in these patients who now need cataract surgery?"
1. Conti FF, Qin VL, Rodrigues EB, et al. Choriocapillaris and retinal vascular plexus density in diabetic eyes using split-spectrum amplitude decorrelation spectral-domain optical coherence tomography angiography. 2018 May 23. pii: bjophthalmol-2018-311903. doi: 10.1136/bjophthalmol-2018-311903. [Epub ahead of print]
2. DCCT Research Group. The Relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial. Diabetes. 1995;44:968-983.
3. Schauer PR, Bhatt DL, Kirwan JP et al. for the STAMPEDE Investigators. Bariatric Surgery versus Intensive Medical Therapy for Diabetes-5-Year Outcomes. N Engl J Med. 2017;376:641-651. Doi: 10.1056/NEJMoa1600869
4. Matsuda S, Tam T, Singh RP, et al. The impact of metabolic parameters on clinical response to VEGF inhibitors for diabetic macular edema. J Diabetes Complications. 2014;28:166-170. doi: 10.1016/j.jdiacomp.2013.11.009
5. Singh RP, Habbu K, Ehlers JP, Lansang MC, Hill L, Stoilov I. The impact of systemic factors on clinical response to ranibizumab for diabetic macular edema. Ophthalmology. 2016;123:1581-1587. doi: 10.1016/j.ophtha.2016.03.038
6. Singh RP, Lehmann R, Mantel J, et al. Nepafenac 0.3% after cataract surgery in patients with diabetic retinopathy. Results of 2 randomized phase 3 studies. Ophthalmology. 2017;124:776-785.