Diabetic macular edema (DME) patients with baseline macular nonperfusion had more advanced disease. When comparing treatments in those patients, aflibercept (Eylea, Regeneron Pharmaceuticals) led to a greater improvement in macular perfusion status as well as visual and anatomic improvement by week 100.
The post-hoc analysis came from the VIVID and VISTA trials, which were 2 parallel, phase III, randomized, multicenter, double-masked trials in patients with clinically significant DME, according to Dilsher S. Dhoot, MD, Retina Consultants, Santa Barbara, CA.
Patients had central involvement and an ETDRS best-corrected visual acuity of 20/40 to 20/320. Patients were randomized to receive 1 of 2 different dosings schedules of aflibercept or they were part of a control arm receiving a laser treatment. The study continued through week 148.