Experimental animal studies showed that administering triamcinolone acetonide-a steroid with anti-inflammatory properties-into the suprachoroidal space of rabbit and pig eyes (using microneedles inserted anteriorly near the limbus) resulted in higher concentrations of the drug in the posterior retina than anterior segment structures such as the lens or trabecular meshwork, allowing treatment of ocular inflammation with lower risks of cataracts and IOP elevation.
However, while the pharmacokinetics of suprachoroidal drug delivery have been investigated in animal models, the ocular distribution and anatomic effects in human patients have not been thoroughly explored.
Glenn Yiu, MD, PhD
E: [email protected]
This article was reviewed by Dr. Yiu. Dr. Yiu has no financial interest in any aspect of this report.