Enhanced-depth imaging OCT
A study recently published in the American Journal of Ophthalmology (2018;186:144-151) set out to evaluate the choroidal and suprachoroidal changes after suprachoroidal injection of triamcinolone acetonide using enhanced-depth imaging optical coherence tomography (EDI-OCT) in patients enrolled in the TANZANITE study.
The Suprachoroidal Injection of Triamcinolone Acetonide with Intravitreal Aflibercept in Subjects with Macular Edema due to Retinal Vein Occlusion (TANZANITE) study was a prospective, randomized, phase II, multicenter clinical trial that compared the effects of a single suprachoroidal injection of triamcinolone acetate suspension (CLS-TA, Clearside Biomedical) delivered using microneedles and an intravitreal injection of aflibercept (Eylea, Regeneron Pharmaceuticals) versus intravitreal aflibercept alone in eyes with RVO and macular edema.
Both the combination and monotherapy groups were then followed monthly and received additional intravitreal injections of aflibercept as needed over 3 months based on pre-defined re-treatment criteria.
Glenn Yiu, MD, PhD
E: [email protected]
This article was reviewed by Dr. Yiu. Dr. Yiu has no financial interest in any aspect of this report.