To shed more light on the genesis of type 3 NV, Dr. Freund and colleagues attempted to correlate in vivo OCT findings with post-mortem histologic findings in a patient with AMD who was treated with anti-VEGF therapy.
In this case, an 86-year-old Caucasian woman had type 3 NV secondary to AMD in her right eye that was treated with six intravitreal injections of bevacizumab (Avastin, Genentech). Geographic atrophy was present in the left eye and reticular pseudodrusen were present bilaterally.
At the initial visit, visual acuity in the right eye with type 3 NV was 20/80. OCT was performed each month out to 6 months and included serial near-infrared reflectance and eye-tracked SD-OCT. This retinal imaging was correlated with ex vivo and high-resolution histologic images of the preserved donor eye evaluated at month 10. Clinical improvement was apparent in the images over time.
The main outcome measures included reflectivity of the vascular complex, intraretinal hyperreflective foci and intraretinal cellularity, analysis of the topography of pathologic features, and evaluation of the sub-RPE and the basal lamina (BL) space.