Clearing the VEGF burden
“Bevacizumab pretreatment helps clear the initial VEGF burden,” Dr. Boyer explained. “ALG-1001 turns off VEGF production, angiogenesis, and reduces inflammation. Adding 1 bevacizumab pre-treatment in the stage 2 study improved the BCVA achieved with 1.0 mg of ALG-1001 by about 40%, compared to the 1.0-mg dose of ALG-1001 without bevacizumab pre-treatment in the stage 1 study. In the two combination arms, no increased efficacy over monthly bevacizumab was seen.”
Dr. Boyer believes that these results are promising. “An important consideration is that ALG-1001 might be efficacious for the 50% of the patients with DME who have not had an adequate respond to repeated anti-VEGF treatments alone,” he added.