The data analysis also showed that 50% of eyes had lesions that reactivated with the first year of the maintenance period, with the most frequent time to reactivation at 8 weeks. This occurred in 17.4% of eyes.
“The long-induction eyes reactivated sooner than the short-induction eyes,” Dr. Gillies said.
When considering the risk of recurrence of the first lesion, the study found, “The risk of reactivation by visit increased with increasing interval, increasing substantially beyond 12 weeks and reaching 36.5% if the interval was 20 weeks or more from the previous injections,” Dr. Gillies pointed out.
At 16 weeks, the risk of reactivation was 5.6% compared with 15.6% at 20 weeks. Eyes with a longer induction phase had worse visual outcomes in the maintenance phase, and earlier and more frequent disease reactivation, although they received injections less frequently, according to Dr. Gillies.