Will OCTA assist ROP diagnosis?
When obtaining images from babies with ROP, Dr. Campbell explained that clinicians need to determine whether there is added clinical value to this technology, or whether it is just a novel way to look at the developing retinal vasculature.
There are a few reasons why the technology might help in caring for these children.
One is that OCTA can visualize extraretinal neovascularization, which is a critical threshold in disease severity staging, known as stage III. Dr. Campbell offered an example of how OCTA would visualize persistent stage III after treatment that was not observed clinically.
“The cross-sectional OCTA images clearly showed the presence of residual flow above the internal limiting membrane near the border of the perfused and non-perfused retina,” he noted.
A second reason is that quantification of the area of neovascularization might provide an objective biomarker of disease severity that can be tracked over time, he explained.
Third, OCTA can also demonstrate retinal nonperfusion and avascularity with improved contrast over those seen on the corresponding FA images.