Lead to objective diagnosis
“There are several ways this technology might lead to objective diagnosis of plus disease,” Dr. Campbell said. “The Duke group first popularized the idea that there may be structural OCT biomarkers of plus disease, and devised a scale called the VASO score for plus disease evaluation.”
Functional OCT using Doppler OCT may provide another method. “Our hypothesis is that total retinal blood flow, which can be measured using this technology, will correlate with the spectrum of changes seen in pre-plus and plus disease, and may correlate with en face area of stage III disease,” Dr. Campbell said.
Dr. Campbell and colleagues are carrying out a prospective study to evaluate all of these hypotheses in ROP using their hand-held device to obtain wide-field en face OCTA images.
The hope is that as laser speeds increase so will the area covered by OCT. “High-speed OCT can do more than just OCTA, and the ability to obtain wider field structural OCT may have its own added utility in ROP evaluation,” Dr. Campbell said.