Subretinal hyperreflective material (SHRM) is a morphologic component seen on optical coherence tomography (OCT) images as hyperreflective material that is external to the retina and internal to the retinal pigment epithelium (RPE), said Jaya B. Kumar, MD.
SHRM has a detrimental effect on vision in eyes with neovascular age-related macular degeneration (nAMD), said Dr. Kumar, a vitreoretinal fellow at Cleveland Clinic, Cleveland.
Investigators found that SHRM that was taller, had a layered appearance, increased reflectivity, and larger size were associated with worse visual acuity at the 12- and 24-week follow-up examinations.
Dr. Kumar and colleagues have reported previously that larger SHRM is associated with poor visual outcomes and the lesion size does decrease with treatment.
“Many researchers have postulated that SHRM is comprised of scar tissue, fluid, and perhaps hemorrhage, but morphologic data about SHRM are limited as is knowledge about its effect on visual acuity,” Dr. Kumar said.