Guiding treatment decisions
The technology may help guide treatment decisions. For example, a retina specialist may perform a clinical exam in a patient with DR, but then ultra-widefield angiography may detect a greater burden of disease.
“That can change prognosis and how one may manage the condition, such as with anti-vascular endothelial growth factor agents or retinal photocoagulation,” he said.
Dr. Wykoff also uses ultra-widefield imaging to document and track pathology, including retinal tears, retinal detachments, ocular tumors, and areas of inflammation.
“It’s helpful to objectively document areas of pathology with a single capture,” he said.
“Peripheral information seen in ultra-widefield color and fluorescein angiography have been shown to alter risk assessment and treatment plans in conditions such as diabetes and uveitis,” McCallum said.
Researchers are exploring ways to use ultra-widefield imaging, including for telemedicine screening, aging eye trends, and even for potential signs of Alzheimer’s disease. Clinicians are also analyzing the advantages of using ultra-widefield imaging to track DR in an ongoing, large, multicenter prospective study, Dr. Wykoff said.
Despite its potential, he cautioned that ultra-widefield imaging does not replace a dilated eye exam.
“The only way to see the entire retina in most eyes is to perform a scleral depressed examination in all directions,” he said.
Ultra-widefield imaging can be particularly limited in the inferior quadrants. he added.
Dr. Wykoff’s research involvement with ultra-widefield imaging includes work towards accounting for the warping inherent to ultra-widefield imaging1 as well as its application to clinical trials such as the WAVE trial.2
Going forward, Dr. Wykoff would like to see ultra-widefield imaging extend even further peripherally, particular to the ora seratta in all directions, and believes that integration of software algorithms for image interpretation will be used to quantify levels of pathology including DR severity levels in the near future.
1. Croft DE, van Hemert J, Wykoff CC et al. Precise montaging and metric quantification of retinal surface area from ultra-widefield fundus photography and fluorescein angiography. OSLI Retina. 2014 Jul-Aug;45:312-317.
2. Wykoff CC, Ou WC, Wang R, et al. Peripheral laser for recalcitrant macular edema owing to retinal vein occlusion: The WAVE trial. Ophthalmology. 2017;124:919-921.
Charles C. Wykoff, MD, PhD