Decrease in mean CST
The anatomic improvements also were significant, with a decrease in the mean CST to 265 µm. More than half (54%) of the retinas were dry, as seen on optical coherence tomography (OCT) images at 6 months. Subretinal fluid resolved in all eyes by the 6-month evaluation, according to Dr. Ehlers.
Dr. Ehlers pointed out that the ultra-widefield angiography images showed qualitative improvements in leakage, microaneurysms, and macular and peripheral ischemia in the study eyes.
“Quantitatively, we observed a reduction in microaneurysms between baseline and the 6-month evaluation,” he added. “Interestingly, we saw this predominantly in the posterior pole.”
Regarding leakage, Dr. Ehlers noted significant improvements from baseline to month 6 in both the number of leakage foci and the leakage index in the posterior pole and in the periphery. The leakage index showed an 83% reduction over 6 months. Ischemic index also decreased by a mean of 53%.