Editor’s Note: Ophthalmology Times is pleased to announce Peter H. Tang, MD, PhD, vitreoretinal surgery fellow, Stanford University Byers Eye Institute, Palo Alto, CA, as the second-place honoree of the inaugural Ophthalmology Times Research Scholar Honoree Program. Dr. Tang’s abstract is featured here.
The Ophthalmology Times Research Scholar Honoree Program is dedicated to the education of retina fellows and residents by providing a unique opportunity for fellows/residents to share notable research and challenging cases with their peers and mentors. The program is supported by unrestricted grants from Regeneron Pharmaceuticals and Carl Zeiss Meditec Inc.
Elizabeth Atchison, MD, senior fellow, Rush University and Illinois Retina Associates Chicago, is the first-place honoree of the Ophthalmology Times Research Scholar Honoree Program. Her abstract is featured at ModernRetina.com/Atchison. Look for more case study honorees in future issues.
RPE65 protein dysfunction disrupts retinal metabolism of vitamin A leading to Leber congenital amaurosis (LCA), a congenital retinal dystrophy characterized by early-onset cone death and progressive vision loss. Human LCA is recapitulated in the RPE65 gene knockout (RPE65-/-) mice.
Previous studies of mice with genetically engineered dendritic cells (DCs) expressing green fluorescent protein (GFP) show that these cells were attracted to retinal injury. In our study, we asked if apoptotic photoreceptor cell death in RPE65-/- mice induced a retinal response that involved these DCs.