What's in a name? When it comes to ophthalmology, a lot. Persistent hyperplastic primary vitreous—an old name that addressees only the status of the primary vitreous—needs updating, said Michael Trese, MD.
Persistent fetal vasculature syndrome (PFVS), coined by Morton Goldberg, MD, seems more relevant because PFVS includes both the primary vitreous and the tunica vasculosa lentis (TVL).
"PFVS is a vitreoretinal dystrophy," said Dr. Trese, clinical professor of ophthalmology, Eye Research Institute, Associated Retinal Consultants, Oakland University, William Beaumont School of Medicine, Royal Oak, MI.
During normal development, the vessels fill the vitreous cavity. Usually the largest is the hyaloid artery from the disc to the lens in the area of the Mittendorf dot. This involutes by apoptosis beginning at 28 weeks of gestational age and is complete by the time of birth usually leaving Cloquet's canal. The vessels that engulf the lens, the TVL, generally regress in a similar fashion, according to Dr. Trese.
Three presentations of PFVS have been recognized.
Michael Trese, MD
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Dr. Trese has no financial interest in any aspect of this report.