Targeted subretinal surgery for delivery of a novel biosynthetic retinal pigment epithelial (RPE) monolayer in eyes with advanced dry age-related macular degeneration (AMD) has been shown to be feasible using new intraoperative surgical methods said Amir H. Kashani, MD, PhD.
Speaking at the 37th annual meeting of the American Society of Retina Specialists in Chicago, Dr. Kashani described exploratory findings from the intraoperative experience and surgical data of patients enrolled in a Phase 1/2A study evaluating the efficacy and safety of the investigational implant.
Dr. Kashani is assistant professor of clinical ophthalmology, Keck School of Medicine of USC, Los Angeles, CA.
Known as the California Project to Cure Blindness RPE 1 (CPCB-RPE1), the 3.5 mm x 6.25 mm implant is comprised of a human embryonic stem cell-derived RPE monolayer on an ultrathin synthetic parylene substrate.
“With the emergence of cell-based therapies, targeted delivery to specific regions of the retina is increasingly important,” Dr. Kashani said. “We have demonstrated the feasibility of a surgical method that specifically targets the area of geographic atrophy (GA) for RPE replacement.”
Dr. Kashani is principal investigator of the clinical trial funded by Regenerative Patch Technologies through the University of Southern California. Dr. Kashani receives honoraria, grant support and speaking fees from Carl Zeiss Meditec.