Adverum Biotechnologies Inc. shared nonclinical data at ARVO 2023 in New Orleans that staggered, bilateral administration of Ixo-vec in NHPs was well tolerated with encouraging therapeutic activity and no signals of increased inflammation.
Adverum Biotechnologies Inc. shared nonclinical data at ARVO 2023 in New Orleans that staggered, bilateral administration of Ixo-vec in NHPs was well tolerated with encouraging therapeutic activity and no signals of increased inflammation. (Image Credit: kittyfly/Adobe Stock)
Adverum Biotechnologies Inc. shared new data in an oral presentation at the Association for Research in Vision and Ophthalmology (ARVO) 2023 Annual Meeting in New Orleans. This nonclinical data supports the two doses of ixoberogene soroparvovec (Ixo-vec, formerly referred to as ADVM-022) being evaluated in the Phase 2 LUNA trial and the potential for staggered, bilateral administration in the treatment of wet AMD.
“The nonclinical data presented today support the two doses we are evaluating in the ongoing LUNA trial of Ixo-vec for the treatment of wet AMD, both in terms of tolerability and aflibercept levels within the targeted therapeutic range,” Brigit Riley, PhD, chief scientific officer at Adverum Biotechnologies, said in a statement. “Additionally, we are encouraged by the results of our nonclinical study evaluating staggered, bilateral administration as approximately 10% of patients convert from single eye to bilateral disease per year, representing an important area of unmet need that warrants clinical evaluation of Ixo-vec in bilateral wet AMD.”