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Innovations for Sustained Anti-VEGF Delivery in Retinal Diseases 

clinical

Tyrosine Kinase Inhibitors to Prolong Efficacy of Anti-VEGF Therapies

Video content above is prompted by the following:

If TKIs become available, how would this impact the relative benefits of PDS?

Videos

Panelists discuss how the chronic nature of retinal diseases requires consistent VEGF suppression through regular anti-VEGF injections, but this treatment burden leads to challenges including patient compliance, health care resource strain, and quality of life impacts from frequent office visits.

Need for Sustained Delivery of Anti-VEGF in Retinal Diseases

Panelists discuss how the port delivery system (PDS) is a permanent, refillable ocular implant that continuously releases ranibizumab into the vitreous, with the Archway trial demonstrating noninferior vision outcomes compared with monthly ranibizumab injections while reducing treatment burden through 6-month refill intervals.

Overview of Port Delivery System With Ranibizumab

Panelists discuss how successful port delivery system (PDS) implantation requires careful patient selection and meticulous surgical technique to minimize complications like vitreous hemorrhage and endophthalmitis, with certain patients being poor candidates due to factors such as active inflammation, thin sclera, or glaucoma filtering devices.

Adverse Effects Associated With PDS and Surgical Considerations

Panelists discuss how surgeons must complete specialized training and certification through the risk evaluation and mitigation strategy program to perform port delivery system implantation, which requires a sterile operating room environment and specific surgical instruments designed for the procedure.

Navigating the Surgical Learning Curve for Effective PDS Implantation

Panelists discuss how patients experiencing frequent anti-VEGF treatment burdens with 4- to 8-week intervals between injections are ideal candidates for PDS as an alternative delivery method.

Patient Selection for PDS

Panelists discuss how the port delivery system (PDS) refill procedure, while performed in an office setting, involves a different technique of accessing and replenishing the implant’s drug reservoir through the conjunctiva and requires specialized training compared with standard intravitreal injections.

Technique for Refilling the PDS

Panelists discuss how the potential availability of tyrosine kinase inhibitors (TKIs) could diminish some advantages of the PDS system, as oral medications would provide an alternative approach to reducing injection burden while potentially offering broader therapeutic effects.

Tyrosine Kinase Inhibitors to Prolong Efficacy of Anti-VEGF  Therapies

Tyrosine Kinase Inhibitors to Prolong Efficacy of Anti-VEGF Therapies

EP: 1.Need for Sustained Delivery of Anti-VEGF in Retinal Diseases

EP: 2.Overview of Port Delivery System With Ranibizumab

EP: 3.Adverse Effects Associated With PDS and Surgical Considerations

EP: 4.Navigating the Surgical Learning Curve for Effective PDS Implantation

EP: 5.Patient Selection for PDS

EP: 6.Technique for Refilling the PDS

EP: 7.Tyrosine Kinase Inhibitors to Prolong Efficacy of Anti-VEGF Therapies