ARVO 2023: Apellis Pharmaceuticals presented Phase 3 data analyses of pegcetacoplan injection for GA
Apellis Pharmaceuticals Inc. delivered an oral presentation at the ARVO Annual Meeting in New Orleans announcing their post hoc analyses from the Phase 3 OAKS and DERBY studies evaluating pegcetacoplan injection (Syfovre) for the treatment of geographic atrophy (GA).
ARVO 2023: Nonclinical data by Adverum Biotechnologies regarding potential treatment of wet AMD
Adverum Biotechnologies Inc. shared nonclinical data at ARVO 2023 in New Orleans that staggered, bilateral administration of Ixo-vec in NHPs was well tolerated with encouraging therapeutic activity and no signals of increased inflammation.
Plans for Phase 2b Clinical Trial of CLS-AX for treatment of wet AMD announced
Clearside Biomedical plans to open enrollment for their Phase 2b clinical trial of CLS-AX this quarter. Topline results are expected by the Q3 of 2024.
Apellis launches new GA Won't Wait campaign with actor Henry Winkler
New GA Won't Wait campaign partners Apellis Pharmaceuticals Inc. with actor Henry Winkler. The goal of this campaign is to raise awareness and educate older adults and their families about geographic atrophy (GA).
Pearls for cataract surgery with Vance Thompson
Vance Thompson, MD, joined David Hutton, Managing Editor, Ophthalmology Times®, to provide an overview of his presentation on pearls for cataract surgery at the Real World Ophthalmology meeting.
Jennifer Lim shares research on vitrectomy combined with KPro surgery
Jennifer Lim, MD, FARVO joined David Hutton, Managing Editor, Ophthalmology Times®, to discuss her presentation on keratoprosthesis combined with vitrectomy surgery given at this year's Vit-Buckle Society meeting.
FDA grants fast track designation for KPI-012 by Kala Pharmaceuticals
Kala Pharmaceuticals KPI-012 receives FDA Fast Track designation as treatment for PCED with potential to treat retinitis pigmentosa and Stargardt disease.
3 key pearls for pediatric retinal surgery
J. Peter Campbell, MD, MPH, sat down with David Hutton, Managing Editor, Ophthalmology Times®, to discuss pediatric retina surgery and 3 key pearls to consider while performing the surgery.
Gene variants point to a potential cause of age-related macular degeneration
According to National Eye Institute researchers, the variants generate malformed proteins that alter the stability of the membrane attack complex, which may drive a chronic inflammatory response in the retina.
Endogena Therapeutics completes dose escalation in Phase 1/2a clinical trial of EA-2353 for treatment of retinitis pigmentosa
No clinically relevant or dose-limiting adverse events were identified after repeated intravitreal injections.
Alimera, Horus Pharma expand agreement to include marketing Iluvien in the Nordic countries
According to the companies,Horus will increase Iluvien’s commercial presence with Nordic retinal specialists.
Nanoscope Therapeutics reveals positive topline results from RESTORE trial of MCO-010 for treatment of RP
According to the company, clinically meaningful visual acuity gains were observed in several MCO-010 treated patients. The trial also demonstrated a favorable safety profile for MCO-010 with no serious or severe adverse events.
FDA-approved drug demonstrates potential in lab models for blinding childhood disease
According to National Eye Institute researchers, the strategy may speed the delivery of therapeutic options relative to time it would take to develop gene therapies.
New form of omega-3 could prevent visual decline linked with Alzheimer’s disease
By crossing into the retina, researchers have found a new DHA supplement achieves what previous ones could not.
Possible expansion of prior authorization to Medicare Fee For Services draws objections from American Academy of Ophthalmology
The Centers for Medicare and Medicaid Services accepted comments on the proposed rule and several organizations, including the American Academy of Ophthalmology, chimed in with comments and offered suggestions.
Retinal scans provide a non-invasive, inexpensive method to track aging
A team of researchers at Buck Institute, working with Google Health and Zuckerberg San Francisco General Hospital, are studying the eye as a window into human aging.
SamaCare partners with AmerisourceBergen to offer prior authorization platform to specialty practices
The partnership will offer specialty physician practices across retina and other specialties access to SamaCare's platform.
Study: Cones in retinal degeneration, believed to be dormant, may retain visual function
According to a team of researchers at UCLA, the “dormant” cone photoreceptors might actually continue to drive retinal activity for vision.
Ocugen announces FDA Approval for enrollment of pediatric patients in ongoing OCU400 Phase 1/2 Clinical Trial for the treatment of retinitis pigmentosa and Leber congenital amaurosis
The FDA has approved enrolling pediatric patients in the ongoing OCU400 Phase 1/2 trial who have: 1) RP associated with NR2E3 and RHO mutations and 2) LCA associated with CEP290 gene mutations.
Unity Biotechnology announces results from Phase 2 ENVISION study of UBX1325 in patients diagnosed with wet AMD
According to the company, UBX1325 monotherapy did not achieve non-inferiority through 24 weeks due, in part, to an unexpected 3.5 letter gain in the anti-VEGF control arm.
Abeona Therapeutics announces update on AAV ophthalmology program
The company is advancing AAV-based gene therapy candidates toward IND studies on encouraging animal proof of concept data in Stargardt disease, X-linked retinoschisis and autosomal dominant optic atrophy.
Researchers find eye color genes are key for retinal health
According to researchers at the Max Planck Institute, the Kynurenine pathway is not only important for eye pigment formation, it also plays a role in maintaining retinal health.
COPHy 2023: Importance of OCTA in clinical practice
Angela Carneiro, MD, PhD, discusses her position on a discussion titled Presence of Macular Neovascularization on OCTA is Predictive of Subsequent Exudation with David Hutton, Executive Editor, Ophthalmology Times®.
COPHy 2023: Durability associated with multi-target therapies is superior to anti-VEGF mono-target therapy in AMD
Antonio Campos, MD, PhD, discusses his position on a discussion titled Durability Associated with Multi-target Therapies is Superior to anti-VEGF Mono-target Therapy in AMD with David Hutton, Executive Editor, Ophthalmology Times.®
Researchers study frequency of retinopathy in patients diagnosed with type 2 diabetes mellitus
According to researchers, diabetes mellitus is caused by higher levels of blood glucose due to the lack of production of insulin by the body, resistance to insulin, or both.
Gene-editing technique reverses vision loss in mice
Researchers are using a new, highly versatile form of CRISPR-based genome editing with the potential to correct a wide variety of disease-causing genetic mutations.
LumiThera reveals sustained vision improvement for 24 months in dry AMD clinical trial data
PBM treatment showed a statistically significant slowing of disease progression in patients with early to intermediate dry AMD.
Report: Physician payments should be tied to inflation-based index
To support congressional action, 135 health organizations – including the American Academy of Ophthalmology – sent a letter to congressional leaders pointing out that a full inflation-based update is the primary solution to the ongoing problem with the Medicare Physician Fee Schedule.
Intergalactic Therapeutics announces positive preclinical results of Its non-viral gene therapy platform in ABCA4 retinopathies
The results support plan to advance lead program in ABCA4-related retinopathies into the clinic in 2024 and expansion into other ophthalmology indications.
UF Health researchers’ gene therapy for retina disorder shows promise in early testing
According to a University of Florida Health, the researchers used gene therapy to both knock down and replace malfunctioning genetic material that affects light-sensing photoreceptors in the retina.
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