Ophthalmology

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Bone marrow cells show promise in degenerative, ischemic retinal diseases

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The safety and feasibility of intravitreal autologous CD34+ bone marrow cells as a potential therapy for retinal disease were evaluated in a pilot study. Preliminary findings demonstrated the treatment was feasible and researchers intend to pursue a larger, prospective study with longer follow-up.

Nitrosative & oxidative stress is associated with structural changes

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In this article, the authors present their recent study results. The study findings demonstrated, for the first time, that in vivo structural changes in ISel band and RPE are associated with increased plasma nitrosative and oxidative stress.

High-res device gives retinal imaging a facelift

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Retinal disease has been given a new face thanks to increased details of the adaptive optics scanning laser ophthalmoscope (AO-SLO), according to Mina Chung, MD.

Drug-delivery micropump for chronic retina disorders

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A novel ophthalmic micropump system, implanted through minimally invasive surgery, is able to deliver the appropriate amount of drug needed at determined intervals, according to Mark S. Humayun, MD, PhD.

Jackson Memorial Lecture: Past, present and future outlook of retinoblastoma

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“Retinoblastoma is a remarkable ophthalmology success story in which the efforts of ophthalmologists, ophthalmic pathologists, and research scientists have led to understanding of the basic mechanisms of cancer and targeted therapies that are able to cure a once incurable tumor,” said Hans E. Grossniklaus, MD, MBA. He was honored as the recipient of the 71st Jackson Memorial Lecture Award in the opening session of the annual meeting of the American Academy of Ophthalmology.

Retinal inflammation: Novel drug delivery

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Nanomedicine that targets activated microglia and neuro-inflammation may one day be a potential therapy for age-related macular degeneration (AMD), diabetic retinopathy, and other eye diseases, said Rangaramanujam Kannan, PhD.

Outlook for integrin peptide therapy

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ALG-1001 is the first of a new class of drugs, integrin peptide therapy, now going through clinical trials for patients with age-related macular degeneration, diabetic macular edema, and vitreomacular traction.

FDA clears NIDEK OCT system

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NIDEK’s optical coherence tomography system-the RS-3000 Advance-has received FDA clearance.

The vitreous: Orphan of the eye

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Ongoing research at the University of Washington-St. Louis suggests that degeneration of the vitreous is implicated, not only in retinal conditions, but in cataract and glaucoma as well.

Combined steroids, anti-VEGFs show promise in DME

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For some patients with diabetic macular edema, treatment with anti-vascular endothelial growth factor agents may not be enough. Clinicians need to consider other options, including dexamethasone implants.

Critical retinal development gene identified

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Researchers at John Hopkins Medicine have announced they have identified a gene that guides the separation of two types of motion-sensing cells, offering insight into how cellular layering develops in the retina, with possible implications for the brain’s cerebral cortex.