The ranibizumab biosimilar is a recombinant antigen-binding fragment (Fab).
Enzene Biosciences, based out of Pune in India, has announced the launch of ranibizumab, a biosimilar to Lucentis, which is sold under the name Accentrix in India.1-3
The ranibizumab biosimilar is a recombinant antigen-binding fragment (Fab) that is used in therapy for neovascular age-related macular degeneration (AMD). It is also the company’s 7th biosimilar following the launch of Bevacizumab for the treatment of metastatic colorectal cancer.1-3
The biosimilar showed comparative clinical efficacy to Lucentis in phase 3 clincial studies and is produced using the company’s “state-of-the-art MAR system” at its plant in Chakan, Pune.1
Himanshu Gadgil, PhD, CEO, Enzene Biosciences said, “Prior to Ranibizumab, our teams have successfully delivered 6 commercial biosimilars and supported our partners with clinical supplies of novel biologic entities (NBE’s), such as monoclonal antibodies (mAbs) and multi-specific molecules."1
Enzene’s Ranibizumab matches competitors in terms of product purity and is designed to bind and inhibit vascular endothelial growth factor (VEGF-A), thereby interrupting the interaction of VEGF with its receptors.1
Enzene is actively progressing with the development of 3 additional biosimilars in various stages and plans to expand into markets like the USA soon.