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Retinal inflammation: Novel drug delivery

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Nanomedicine that targets activated microglia and neuro-inflammation may one day be a potential therapy for age-related macular degeneration (AMD), diabetic retinopathy, and other eye diseases, said Rangaramanujam Kannan, PhD.

Outlook for integrin peptide therapy

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ALG-1001 is the first of a new class of drugs, integrin peptide therapy, now going through clinical trials for patients with age-related macular degeneration, diabetic macular edema, and vitreomacular traction.

FDA clears NIDEK OCT system

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NIDEK’s optical coherence tomography system-the RS-3000 Advance-has received FDA clearance.

The vitreous: Orphan of the eye

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Ongoing research at the University of Washington-St. Louis suggests that degeneration of the vitreous is implicated, not only in retinal conditions, but in cataract and glaucoma as well.

Combined steroids, anti-VEGFs show promise in DME

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For some patients with diabetic macular edema, treatment with anti-vascular endothelial growth factor agents may not be enough. Clinicians need to consider other options, including dexamethasone implants.

Critical retinal development gene identified

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Researchers at John Hopkins Medicine have announced they have identified a gene that guides the separation of two types of motion-sensing cells, offering insight into how cellular layering develops in the retina, with possible implications for the brain’s cerebral cortex.

Determining ocriplasmin success

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A new agent aimed at treating symptomatic vitreomacular adhesion can affect patients differently depending on several components.

Understanding genetic risk factors for AMD

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A better understanding of how genetic risk factors influence the trajectory of age-related macular degeneration may be key to solving the puzzles of this disease. Ocular tissue research may play a role in that process.

Ultra-widefield FA vital for recalcitrant DME

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Ultra-widefield fluorescein angiography may help improve treatment in patients with recalcitrant diabetic macular edema by visualizing areas of peripheral nonperfusion that can benefit from targeted photocoagulation.

Laser treatment necessary for DME

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Lasers continue to have a place in the treatment of diabetic macular edema with foveal involvement despite the advent of anti-VEGF therapy.

What’s next in the neovascular AMD pipeline?

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The therapeutic pipeline for neovascular age-related macular degeneration (AMD) contains a host of promising investigational agents. Only time will tell how any one will shape the future of AMD management.

ARVO 2013: Sight set on world-class science

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Though the scenic backdrop of the Pacific Northwest at this year’s meeting of the Association for Research in Vision and Ophthalmology (ARVO) may have been different from the traditional Floridian seascape, the meeting’s world-class science continues to be at the forefront.

Vitreous history in the making

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Much has changed since the early days of vitrectomy, as exemplified in ophthalmic texts

Jetrea gets NICE reimbursement recommendation

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United Kingdom’s National Institute for Health and Care Excellence (NICE) has provisionally recommended ocriplasmin (Jetrea, ThromboGenics NV) for reimbursement within the National Health Service (NHS).

Retina Summit to precede ARVO

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The Cole Eye Institute will present a Retina Summit CME symposium immediately before the ARVO 2013 annual meeting.

Optos gets 510(k) for microperimetry

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Optos plc has received 510(k) clearance from the FDA for microperimetry as part of the OptosOCT SLO.

Gene therapy trials in progress

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Gene therapy is making headway in inherited retinal diseases that were previously thought to be untreatable.