Lynda Charters Enoch started her early “eye life” at the Schepens Eye Research Institute, Boston, which ultimately culminated in her current position as an Editor of Ophthalmology Times.
Intravitreal steroid injections associated with a higher incidence of endophthalmitis compared with other intravitreal injections
Investigators reported that intravitreal steroid injections were the bases for more cases of endophthalmitis compared with other intravitreal injections.
Risk of rhegmatogenous retinal detachment rises following cataract surgery
The investigators undertook a study to determine the incidence of rhegmatogenous retinal detachments 1 year after cataract using the IRIS Registry data and to determine the demographic features, ocular comorbidities, and intraoperative factors associated with an increased risk of detachment development.
Identifying risk factors for development of rhegmatogenous retinal detachments in fellow eyes
Patients with a unilateral rhegmatogenous retinal detachment frequently ask about the risk of developing an RRD in their fellow eye.
Fewer ocular symptoms linked to e-cigarettes than traditional cigarettes
Those who used both traditional and electronic cigarettes reported severe to very severe ophthalmic symptoms.
Faricimab for nAMD: Safe, effective, lower treatment burden compared with aflibercept in pooled TENAYA, LUCERNE Phase 3 trials
The AVONELLE-X long-term extension study will continue to evaluate the efficacy, durability, and safety of faricimab in patients with neovascular AMD.
Health care restrictions due to COVID-19 had no negative effects on status of DME
The data analysis showed that the macular thickness decreased across all time periods and in all macular regions for all tertiles.
Acute retinal necrosis: Retinal detachment rates are unaffected by early treatment with intravitreal antivirals, vitrectomy
The results also showed that, compared to use of systemic antivirals alone, treatment with adjunctive intravitreal injections or early pars plana vitrectomy did not affect the time to development of retinal detachments.
Faricimab eradicates center-involved DME faster than aflibercept
The data analysis indicated that patients achieved robust visual gains and central subfield thickness reductions with faricimab dosed every 8 weeks and with PTI dosing up to every 16 weeks. The gains were sustained through year 2 of the trials.
IRIS Registry: Comparing dry eye disease in adult and pediatric populations
Almost 5 million patients in the IRIS Registry had received at least one diagnosis of DED between 2013 and 2019; of those, 203,171 were children under 18 years of age and 4,592,808 were adults.
Continuous range-of-motion IOL scores high in patient satisfaction
Investigators reported that the safety and efficacy of the Tecnis Synergy IOL model ZFR00V indicates that it may be a good option for patients who desire meaningful gains in uncorrected visual acuity at all distances.
Pediatric patients have higher incidence of new strabismus following tube shunt surgery than adult patients
13% of pediatric patients had new-onset strabismus after a tube shunt procedure; in contrast, 0% of adults had new-onset strabismus after tube shunt surgery (at 6 months or at last follow-up).
Phase 3 Sailing Study: Intravitreal conbercept administered as needed improves vision in patients with DME
The drug’s efficacy was reported to be superior to that achieved with laser photocoagulation.
Abnormal ophthalmic findings associated with young patients with brain tumors
Investigators advise an ophthalmologic evaluation at the time of tumor diagnosis to detect early vision loss.
Study finds ranibizumab biosimilar equivalent in safety, efficacy for the treatment of wet AMD
The authors noted that the proportion of patients losing fewer than 15 letters from the baseline BCVA score in the study eye was comparable between the ranibizumab and biosimilar treatment groups.
Zika virus linked with fundus lesions in newborns in French territories
This research team conducted a cross-sectional multicenter study to report the ocular fundus manifestations in infants with congenital ZIKV exposure in French Guiana, Martinique, and Guadeloupe, French West Indies.
Hydroxychloroquine dosing based on ophthalmology guidelines limits SLE flares, may cause retinopathy over time
The investigators emphasized that hydroxychloroquine doses of 5 mg/kg/day or less, in accordance with current ophthalmology and rheumatology guidelines, was associated with a higher risk of lupus flares, and the threshold was near 5 mg/kg/day.
Increased dosing for treatment of X-linked retinoschisis linked with inflammation in AAV-RS1 trials
Investigators have reported good progress in determining how the disease works in the eye; however, a downside is the inflammation that seems to accompany treatment with increased dosing.
Suspension of AMD treatment during the COVID-19 pandemic resulted in increased rates of vision loss
Researchers found that the rate of visual decline increased significantly in patients with age-related macular degeneration during the COVID-19 lockdown who were followed over time.
Acing the suprachoroidal injection for targeted drug delivery
This method of administration facilitates targeted delivery of the medication to the retina and choroid.
The soothing effect of music, white noise for babies during ROP examinations
The white noise and classical music listened to by the preterm infants during ROP examinations showed positive effects on pain and heart rate and oxygen saturation values.
LIGHT study: First analysis of gene therapy for RPE65 inherited retinal dystrophies
At the 1-month evaluation, the full-field stimulus threshold had median decrease of -33.2 decibels (dB) (-33.7; -19.8) dB, which remained stable until the last assessment. Visual fields and visual acuity did not change significantly.
Visual symptoms after COVID-19: Potential for retinal manifestations
They advised that clinicians should be aware of this spectrum of retinal involvement after COVID-19 infections and emphasized the importance of a fundus evaluation.
Increased risk of primary angle-closure glaucoma linked with retinitis pigmentosa
The investigators explained that elevated angle-closure-related intraocular pressure may aggregate the visual impairment in patients with retinitis pigmentosa.
Phase 2 Altitude study interim data analysis: RGX-314 provided 2-step or more improvement in diabetic severity
The Phase 2 Altitude study is an open-label, randomized, controlled, dose-escalation evaluation of RGX-314, evaluating the efficacy, safety, and tolerability of suprachoroidal delivery of RGX-314 in patients with moderately severe/severe non-proliferative diabetic retinopathy or mild proliferative diabetic retinopathy.
Dealing with complications of silicone oil
European investigators describe how they address complications associated with silicone oil endotamponade in vitreoretinal surgery.
Hair cortisol level as a molecular biomarker in retinitis pigmentosa patients
Patients with RP experience greater levels of stress and anxiety than individuals in the general population and that the level of stress can be measured easily and non-invasively in hair.
Investigating possible causes of myopia in schoolchildren aged 3-14 years in Tokyo
Researchers have suggested numerous theories about the etiology of myopia that include accommodative-lag, peripheral hyperopic defocus, light environment, lifestyle, and environment, but the cause remains unknown.
EuroVeRsion case contest: Vitreoretinal fellows video competition
The contest will take place as part of World Retina Day, Saturday, September 3, from 8:30-9:30 CEST in Hall X2/Channel 7.
Women in retina: Raising women to their full potential
The stated core foundation of the Women in Retina program is that “the best innovations happen when diverse people with different perspectives collaborate.” The program will help ESRS harness these perspectives and challenge the way things are done and allow for them to be done better.
Ocular inflammation linked to AAV gene therapy
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